An investigation into the gruesome details of Holmes' infamous Murder Castle leads to the discovery that he may have been killing victims all over Chicago and beyond; a report says the Ripper may have killed in the United States.

Jeff and Amaryllis discover an unexpected connection to the Ripper in police archives while investigating the 1893 World's Fair that turned Chicago into H.H. Holme's killing ground.

H.H. Holmes goes on the run as his schemes unravel; the investigation picks up on Holmes' trail with a long-lost crime scene that could hold the key to proving he's the Ripper.

A trove of mysterious artifacts contain an unexpected link to the U.K. Later, while investigating Holmes’ capture and final days on the run, Jeff and Amaryllis find evidence of the Holmes curse and the theory that the killer escaped his own death.

H.H. Holmes' grave is exhumed in an attempt to prove that he pulled off one final swindle and escaped his own execution.