
Chuck suspects he has gonorrhea and confronts his girlfriend Jane who then confronts her lover/ex-boyfriend Peter, accusing Peter's girlfriend Siska of starting the STD chain. Renzo tries to convince Jim to ask Annie out, but Jim's conversation with Annie's roommate Carla leads him to believe Annie wouldn't date a man in a wheelchair. When Rebecca asks why he got into a fight, Kip confesses that he made it all up.
After meeting in a bar over too much tequila, Kim and Miles wake up handcuffed to Kim's bed frame and find that the key is missing. Mona, who is a lesbian, and her straight twin sister Dominique swap places and hook up with each other's lovers. Vanessa dresses Jamie in drag for a drama exercise, then Jamie uses the disguise to get to know Sabrina better.