The International Response Team heads to Cairo when an Egyptian-American former U.S. serviceman is killed in a gas attack there and his friend goes missing.

The team travels to Japan to assist local law enforcement in investigating homicides made to look like suicides. Meanwhile, Mae encourages Clara to get out and enjoy herself.

The International Response Team heads to Paris to search for an UnSub targeting Americans who live there.

The International Response Team heads to Belize to search for a couple who disappears while on their honeymoon in what appears to be a targeted abduction.

The International Response Team travels to Morocco when a retired couple from Idaho is kidnapped while visiting the country on a cruise.

When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.

When an American girl leaves home to meet her boyfriend in Turkey, the International Response Team suspects she’s in trouble after being tricked by someone posing as her boyfriend.

When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi, a profiler he’s worked with before who has an unorthodox style of investigation.

When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.

The IRT heads to Pamplona, Spain, for the running of the bulls, where the ears of a missing American tourist are found.

When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack and his wife, Karen, prepare to send their daughter to college.