The Big Guy and Rusty the Boy Robot

A telepathy experiment goes awry and a Quark Scientist, Dr. Neugog, is transformed into a giant brain on spidery legs. Neugog uses his telepathic powers to drain the minds of the world's greatest scientists. Meanwhile, Dr. Slate accidentally discovers that there's a man in the Big Guy suit.

Rusty tags along with Dwayne to his nephew's birthday party. Rusty's present is a piece of stolen alien technology, known as a Dimetrium Agglomerator. The aliens, Emek and Naard, own the Agglomerator and come to claim it.

Dr. Gilder, the Legion Ex Machina's mole within Quark, has developed a personal grudge against Donovan, so he takes control of a prototype and tries to assassinate him. Donovan is taken to the S.S. Dark Horse for his own safety. Gilder then hacks into Rusty, gives him a ""big gun"", and sets out to destroy Donovan.

Dr. Slate, Big Guy and Rusty find out that the Legion Ex Machina's mysterious ""final assembly"" is taking place in a network of underground tunnels. When Big Guy and Rusty find the tunnels, they derail a robotic train. Inside the massive train's cargo hold is a gigantic hand that boasts a built-in high-tech cannon. With their plan uncovered, the Legion Ex Machina members decide to activate their latest creation ahead of schedule and missing a hand.