Having collected a photo of the hand of suspect number one Lee enhances it and discovers that the suspect is wearing a A. Nigma High championship football ring and has a scab on his mid-knuckle. Realizing that the scab could be gone by tomorrow Lee sneaks out of detention again and tries out for the football team so that he may check the players for scabs. Lee soon discovers that their water boy is a kleptomaniac who stole the ring and a can of paint from Lee's bag.

Having failed to find the prankster on the previous day, Lee is at a dead end. Luckily Lee encounters a group of students known as the Skaters who state they were responsible for the paint portion of the Prank and request instructions on more pranks from Lee. Misunderstanding Lee's intentions, they plot to rig the Student of the Week vote to come up as Principal General Barrage and dump the remaining paint on him on live TV along with the host Tina and Chaz. Lee is narrowly able to avert the disaster (as he doesn't want Tina to have paint dumped on her) and in the process learns the email address of the prankster, Radcircles@ANigmahigh.

A chance encounter with his old rival, Irwin of the Mathletes, leads Lee to the conclusion that he is Radcircles. Lee sends Holger in during detention to spy on the Mathletes but he is captured and tortured forcing Lee to sneak out to rescue him. Lee confronts Irwin and the latter reveals that while he did send an email to the Skaters, and then some, it was a photoshopped image of himself and Lee to make it look like the latter was picking his nose. In a subplot Cam is attempting to learn the identity of the one who sent the photoshopped image and in the process learns the identity of Radcircles, former principal of A. Nigma High, Principal Wurst.

Lee is blackmailed by his self proclaimed girlfriend Brandy who forces him to attend a party of hers or else the fact that he's been sneaking out of detention will be revealed. In order to avoid the wrath of his overbearing mother Lee attends the party. There he learns the identity of those that composed the music for the Prank, the Dudes of Darkness, which has a hypnotic effect on the other party goers. Unfortunately Lee's mother learns from watching the news that Lee was at the party against her strict demands of grounding, getting him into even more trouble.

Following the events of last Friday Lee is going to see the Dudes of Darkness to Question them about the Prank. He learns that Cyrus recorded the music during the prank has become consumed by the hypnotic effects of the music becoming obsessed about it. Under the hypnotic effects of the music Cyrus quits the Dudes of Darkness. Biff, easily their biggest fan, is furious with Lee and promises retribution if he fails to reunite the band. Lee uses Barrages voice to snap Cyrus out of the trance in time for him and Lee to blow the crowd away at the battle of the Bands. Once home Lee contemplates listening to the Music to learn any information about the Prank, fearing that he might become consumed by it like Cyrus was.

A Nigma High is consumed by a Flu Epidemic, Lee included. Lee's cell phone containing the Prank Song is stolen by the Tazelwurm. Lee chases the Tazelwurm to an underground laboratory, where he learns the Prank Song was developed there. The Tazelwurm gives Lee a folder containing all the information about the Prank. Unfortunately Lee is captured by the Cleaners, is knocked unconscious, and dragged back to detention where he wakes up and writes the experience off as a bad dream. In a Sub plot Holger, Camilio, Brandy, and Chaz are attempting to escape the school before the flu turn them into "Zombies" too, and Principal Barrage does battle with his old enemy "Colonel Von Virus".

Lee receives an email from Radcircles telling him to meet him at the auditions for the annual school play. Disguised as the lead character "Alexander Nigma" Lee arrives on scene and is inadvertently indocturned into the play as the lead character. Facing off against Radcircles in a bizarre game of Cat and Mouse Lee attempts to use the email to contact Radcircles during the play to make him reveal himself unsuccessfully. Brandy, Lee's leading lady, becoming frustrated with Lee, rips his fake beard off, nearly revealing to the crowd his identity. Luckily Biff and Camilio manage to cover for him, and in the process Lee gets back to detention before Barrage dismisses him. While Lee has failed to find Radcircles, he vows to him in an email that he will find him.

Lee is given one day of amnesty from detention as per the rules of the Students charter of rights. But he can't enjoy the day off as he's accidentally incurred the wrath of the fearsome 15th graders when he enters their territory chasing a lead. During the brief period of time in which the Tazelwurm had Lee's phone someone programmed in a series of numbers, a locker number and combination. Inside said locker Lee finds his original bag from the day one prank. However Lee has more pressing matters to attend to, he must deal with the 15th Graders or else they will daunt him for the rest of his high school life. Lee is saved from the 15th graders by the Tazelwurm just in time to avoid further grounding from his mother.

Due to an outbreak of Frogs at the school Barrage and Victoria schedule an emergency field trip to the recently reopened Green Apple Splat company for the entire 10th grade. There a melt down is triggered by some of the students, inadvertently locking the students inside the factory. Barrage and Lee are able to work together to not only save the class from the melt-down but also the fearsome cyborg tazelwurms living inside the factory. In a side plot Lee discovers that the Tazelwurm planted a key like device inside his bag which proves vital in the group's survival, and it's discovered that not only did a trio of environmentalists release the frogs at the school and trigger the melt down but they also released them during the Prank, though they aren't connected to the others in the conspiracy.

When DJ Lynch gets busted for pulling a fire alarm, he gets detention for the day. Lee wants to explore the underground tunnel system and so is forced to bring him along for the ride.

Lee discovers that a "Down with Lee Club" has formed at A. Nigma High as a result of the pranks he pulled in "15th Graders". Worse yet, this Club is now being helped out by Radcircles! Radcircles has a plan to get Lee expelled, to this end Lee is forced to send Camilio in undercover. Camillio discovers that the group is planning a trio of pranks against the staff of A. Nigma high that will unquestionably frame Lee, but it's discovered too late that this is a distraction for the group to steal Barrage's leg and plant it in Lee's locker. Lee and Holger are able to work together to leave the leg somewhere Barrage can find it but away from suspicion.

Tina runs an embarrassing story on the news in which it is revealed that the Glamazons wear hair extensions, prompting Lee to suspect that they will be seeking revenge. Lee sneaks out of detention and goes to the mall to protect Tina in the process discovering that a bag exactly like his was purchased at the mall. Lee is able to call in Zed to distract the clerk while Holger sneaks in and steals the store's security footage. Lee is able to prevent what appears to have been an attempt by Brandy to poison Tina but in reality is an elaborate scheme to break up her and Brad Von Chillschene. Lee is able to hitch-hike his way back to school in time to be dismissed by Barrage. While at home and after watching incredibly large amounts of footage Holger discovers that the only person to have bought a bag like Lee's was none other than Camillio. In a subplot Biffy reconciles with his childhood friend, Kimmie McAdams, while in Detention.

When Chaz reveals he has 'prank footage", everyone has a reason to want to get to it first. Lee decides to help protect Chaz from the pursuing mob for a chance at a first look.