
Danny Fenton hates Christmas. When he accidentally destroys the only copy of a ghostly Christmas story, the book's author, Ghost Writer, makes Danny hate the holiday even more by turning him into the main character of a brand new Yuletide tale. Danny is now trapped in a scenario where everyone talks in rhyme! With his magical Quantum Keyboard, Ghost Writer creates a series of catastrophes that threaten to ruin Christmas for all of Amity Park and pins the blame on Danny. When Danny goes into the Ghost Zone to confront Ghost Writer, he is surprised to find his old ghostly enemies in a giving mood. Danny enlists them to help him defeat Ghost Writer and restore the spirit of Christmas to Amity Park and, perhaps, to his own heart.
Danny and Sam get into a fight, and when Sam utters the words, "I sometimes wish I'd never met you," she finds herself in a world in which she and Danny are strangers. Worse than that, since it was Sam who encouraged Danny to check out the Fenton Portal the night he got his ghost powers, Danny doesn't have any powers! Now, Sam must convince Danny that they share a friendship and a history, and lead him back to the Fenton Portal for a second "accident" so he can again become Danny Phantom.
After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.