Amity Park is in the midst of a drought, and Mayor Vlad, eager to score points, releases Vortex, the weather ghost, to make it rain. But when Vlad double crosses Vortex, the ghost conjures a storm that threatens to drown the town! As Danny Phantom flies to the rescue, he’s zapped by a lightning bolt. When he comes to, he discovers that his emotions are now directly tied to the weather!

Amorpho, a ghost with morphing abilities, impersonates people and gets them into trouble with it. He then impersonates Danny and both of them must learn the price of fame when a fenton device interrupts some of their powers, preventing Danny from returning to his human self and locking the evil shapeshifter in a shape that calls too much attention: Mr. Lancer's.

The Fentons sell Fenton Works to the Guys in White who plan to destroy the Ghost Zone (unaware that Earth will be destroyed too) with a missile; meanwhile, Danny starts to let the rich life get a hold of him and jeopardize his friendship with Sam and Tucker.

Danny and Vlad’s game of revenge against each other begins with childish pranks, and, unfortunately for Danny, ends when Vlad decides to run for mayor of Amity Park! By overshadowing voters, Vlad wins in a landslide. The new mayor is eager to use his new power to make life as miserable as possible for Danny and his friends. He shuts down the Nasty Burger, outlaws technology, creates new school uniforms, and passes so many new laws in the name of “protecting the children” that Danny finds it impossible to go ghost.

As one of the weakest ghost in the Ghost Zone, the Box Ghost attacks with every "deadly box" he has in the human world, but is easily defeated by Danny. He then makes a plan: he will use "Pandora's Box", the most powerful box ever created, and will use the evil and deadly powers inside it to attack Amity Park. Now Danny must find the only one able to save the day: Pandora herself!

Danny wakes up wearing a strange headset in the Ghost Zone. He returns to Amity Park and discovers everyone is asleep thanks to the ghost of sleep, Nocturne, who is sucking up their dreams to increase his energy. Danny must wake his friends and sister in order to stop this threat.

Danny's class goes to a camping trip with Mr. Lancer and Ms. Teslaff to an abandoned place which is seemingly haunted. Soon reports of monster sightings and missing students have the whole camp shook up. Monsters start showing up and disrupting the camping trip. To Danny's surprise, these monsters are ghosts working for Walker, on the hunt for Wulf. Now Danny must save his old friend and his class from Walker!

Dani Phantom has finally returned to Amity Park. Having the trouble of dissolving into nothing worst than ever, she seeks the one person who can help her, her cousin and best friend, Danny Phantom! However, Vlad has been keeping track of her since her last appearance and plans to get his "little girl" back, by duping Valerie Gray into doing it for him. After finding Danielle, she uses her to lure Danny into a trap and now she has two Danny Phantoms trapped! Now stuck in the clutches of Valereie Gray, Danny must find a way to escape and save his cousin from being melted to ectoplasm by Vlad!

Danny, after being publicly shamed by Vlad's new ghost hunting team, wants to be normal again. So he gets rid of his powers by reactivating the Fenton Portal after Jack dismantles it for a software upgrade. However, an asteroid made of Ectoranium threatens the Earth, and Vlad - after revealing to everyone that he is Plasmius - fails to stop it. The world now relies on a powerless Danny to get help from the ghosts in the Ghost Zone!