As the Colts look to move past the .500 mark, Head Coach Frank Reich leads the team into Buffalo, where Reich quarterbacked the greatest comeback in NFL history.

The red-hot Colts, fresh off their 41-16 victory in Buffalo and with growing MVP buzz about second year running back Jonathan Taylor, come home for Thanksgiving and face their biggest test yet: Tom Brady and the Tampa Bay Buccaneers.

Following their closely contested loss to the Buccaneers, the Colts enter a December schedule in which every game is crucial. This week, they travel to Houston to play the Texans – a divisional opponent which veteran wideout T.Y. Hilton has tortured during his 10-year Colts career with explosive performances.

As the Colts enter their bye week, Frank Reich explains why it’s less a vacation than a tool to help recharge for the playoff push. Practicing what the Irsay Family preaches about the importance of mental health, players travel the country to get a break from football.

The Colts gear up for a primetime clash with the New England Patriots, head coach Frank Reich hands the game ball to owner Jim Irsay and dedicates it to the Kelly family after a tragedy inside the organization.

A massive COVID-19 outbreak hits the roster just before the Christmas night game vs the Arizona Cardinals, and the Colts lean on depth and leadership.

With starting QB Carson Wentz sidelined after a positive COVID test, the Colts navigate uncertainty heading into Week 17 vs the Las Vegas Raiders.

The season ends in painful fashion as the Colts face the Jacksonville Jaguars in Week 18.