

In Miami, Godzilla, H.E.A.T., and Major Hicks battle Skeetera, a mutated bloodsucking mosquito-like insect who adapts the powers of the creatures she feeds on. As they attempt to contain the creature they are interrupted by the mutation rights fringe group known as S.C.A.L.E. (Servants of Creatures Arriving Late to Earth).
While Craven is laid up sick back at H.E.A.T. headquarters, Nick, Randy, Elsie and Monique assist Godzilla in a battle with a Mutant Jellyfish. The Heat-Seeker is engulfed by a mysterious storm which propels the team into a bleak, post-apocalyptic future where Godzilla is dead and the world is dominated by genetically engineered, 5-legged mutations known as Dragmas.
Shady promoter Maximillian Spiel entertains wealthy ticket holders with a series of “cage matches” between giant mutations like the Shrewster and the Giant Centipede. For his next bout, Spiel sets his sights on the “ultimate monster”… Godzilla.