A giant hound has been seen-and strangely enough, heard- on the moon. People are worried. It's up to Holmes, Watson, and Lestrade to expose what's happening and to catch who's responsible for it all. Of course, being jumped by the hound along the way doesn't help matters...

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A loud argument between a man and his wife attracts the attention of their housekeeper. The man is then discovered to be missing. The room shows signs of a great struggle, with curious parallel slashes everywhere. It also seems that a great change has come over the wife since her walk that afternoon. Holmes is determined to find out what happened on that walk. The result is amazing.

Holmes fakes madness and babbles about oysters apparently after exposure to a boobytrapped puzzlebox, not infected with mind-altering nanobots. At Midgard Hospital are the suspected nanatech thieves: Dr. Cushing, Dr. Cuthbertson Smith and Dr. Chang. Smith is given away by the surgeons' knot on his retro nonvelcro shoes.

A mysterious and somewhat theatrical vampire is crashing computer grids, swimping codes, invading locked vaults, and causing panic in New London. The only clue is video images of the devil grinning into the camera as he crushes a computer disk in his hand. Lestrade pursues the Sussex vampire with her usual (destructive) aplomb, which rather amuses the detective. Diedre--who has a unique female perspective on things that Holmes cannot for all his smarts manufacture--notes an interesting quirk their foe has while watching hours of old vamp flicks and tapes of the Sussex vamp's little disk-breaking show. Holmes, Watson, and the Baker St. Irregulars pursue the data-sucking fiend into its sewer lair...and meet up with an old ""friend"" of Holmes', who is also looking into the vamp matter.

Dr. Grimsby Roylott uses a snake, not to kill his daughter, but to become a snake-man to steal nanobot technology to save his failed New London Zoo. The clues are a snake scale with hair, a sabotaged hovercraft, the Zoo financial records and the history of the animal rights activists, the Earth Sentinels.

Fenwick and Moriarty's other henchmen assume disguises, using technology invented by Dr. Blessington to make their DNA unrecognizable.

Mary Morstan comes to Holmes with a problem. The solution of that problem, however, will lead them clear to the moon! Mary's father had been killed in a mine accident on the moon years ago. Now Mary is finding out that the circumstances were strange then, and the sequel is even stranger now.

Hilton Cubitt and his wife, Elsie, are devloping a way to grow plants at subzero temperatures. But someone wants their research, and he is willing to kill them for it. Someone breaks in and a struggle ensues, ending with Hilton falling into a cryogenic tank and Elsie out cold beside it. Holmes and the gang arrive to help. Not only must they solve the case, but they must also deal with a nosy cousin, Abe Slaney. They end up finding out quite a bit, involving a strange email with a series of dancing stick figure men and Mrs. Cubitt's past.

The ancient Musgrave sword is stolen from the heavily-guarded museum even though the inscription on it is readily available on the replicas in the souvenir stand. The trail leads to the Musgrave graveyard and on into ""the Abyss"".

Henry Baker loses hat and doll, a GREEN Carbuncle rather than the usual blue one from the Wundygate toy store. It is actually a prototype robot with a human-like personality. Naturally Moriarity wants it. Holmes lets him have it!

The racing vehicle Silver Blaze is missing. Now the owner blames his rival, who blames him back. Holmes must figure out how to get information out of the only one who witnessed the crime: the owner's dog, who barks loudly if anyone unfamiliar comes near. The ending will have Lestrade at the wheel as they fly through asteroids to catch the culprit.

A man receives five orange seeds, or pips in a letter, but they have been tainted with some kind of serum that induces a coma in him. Before succumbing, he writes down an address and gives his son these instructions. Get help from Sherlock Holmes, and under no circumstances is he to be brought to a hospital. Complicating matters, is the family are ""anti-techs,"" people who are strongly against tecnology and robots of any kind, preferring to live in Sherlock's time period. Watson is not exactly welcome...

Carter Wilson is tricked by Vince Spaulding into working for the Red Headed League.

Lois St. Clair asks Holmes to find her husband Neville. The investigation leads to a panhandler with a twisted lip.